Garlic Butter Shrimp Scampi Lasagna: A Seafood Lover’s Dream Dinner

If you love the bold, buttery flavors of shrimp scampi and the warm, comforting layers of lasagna, then get ready to fall in love with this decadent fusion: Garlic Butter Shrimp Scampi Lasagna.

This dish combines garlicky sautéed shrimp, a rich lemon-butter wine sauce, layers of creamy ricotta and mozzarella, and tender lasagna noodles — all baked to bubbling, golden perfection. It’s a show-stopping meal perfect for seafood lovers, special occasions, or when you want to impress without the fuss.

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Why You’ll Love Garlic Butter Shrimp Scampi Lasagna

🧄 Packed with rich garlic-butter flavor
🦐 Full of succulent shrimp in a tangy, buttery scampi sauce
🧀 Layered with creamy ricotta and mozzarella
🍋 A bright hit of lemon and white wine to balance the richness
🔥 Oven-baked for the perfect golden finish
🥂 Elegant enough for date night, dinner parties, or holidays

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What Is Shrimp Scampi Lasagna?

Traditionally, shrimp scampi is a simple dish of shrimp sautéed in garlic, butter, and white wine. In this lasagna version, that buttery garlic shrimp becomes the centerpiece of a creamy, cheesy layered pasta dish — a unique and indulgent twist on Italian-American comfort food.

Instead of tomato-based sauce, this lasagna features a lemony garlic butter sauce and creamy ricotta to highlight the seafood.

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Ingredients

For the Garlic Butter Shrimp:

• 1½ lbs large shrimp, peeled and deveined
• 4 tbsp unsalted butter
• 4 cloves garlic, minced
• ¼ tsp red pepper flakes (optional for heat)
• ½ tsp salt
• ¼ tsp black pepper
• ½ cup dry white wine (or chicken broth)
• 1 tbsp lemon juice
• 1 tsp lemon zest
• 2 tbsp chopped parsley

For the Lasagna Filling:

• 9–12 lasagna noodles, cooked al dente
• 15 oz ricotta cheese
• 1 cup grated Parmesan cheese
• 1 egg
• 2 cups shredded mozzarella cheese
• 1½ cups heavy cream or half and half
• 1 tbsp olive oil

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Optional Additions:

• 1 cup sautéed spinach or baby kale
• ½ cup chopped sun-dried tomatoes
• A sprinkle of Italian seasoning

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Equipment Needed

• 9×13 inch baking dish
• Large skillet
• Medium mixing bowls
• Saucepan for boiling pasta

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How to Make Garlic Butter Shrimp Scampi Lasagna

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Step 1: Prepare the Shrimp Scampi

1. In a large skillet, melt the butter over medium heat. Add garlic and cook for 1–2 minutes until fragrant.
2. Add the shrimp, season with salt, pepper, and red pepper flakes. Cook 2–3 minutes per side, or until just pink.
3. Pour in white wine and lemon juice, simmer for 2 minutes. Remove shrimp and set aside.
4. Let the sauce reduce slightly and stir in the lemon zest and parsley. Remove from heat.

✅ Tip: Don’t overcook the shrimp — they’ll finish baking in the oven.

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Step 2: Cook the Lasagna Noodles

Boil the noodles in salted water until just al dente. Drain and set aside on a tray, separating the noodles with parchment or a drizzle of oil to prevent sticking.

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Step 3: Mix the Cheese Layer

In a bowl, mix:

• Ricotta
• Parmesan
• Egg
• A pinch of salt and pepper

Stir until smooth and creamy.

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Step 4: Assemble the Lasagna

Preheat oven to 375°F (190°C).

Layer in a 9×13 baking dish:

1. Spread a spoonful of scampi sauce on the bottom
2. Layer 3 lasagna noodles
3. Spread ⅓ of the ricotta mixture
4. Add ⅓ of the shrimp, a drizzle of scampi sauce, and a sprinkle of mozzarella
5. Repeat layers until all ingredients are used
6. Pour heavy cream evenly over the top and finish with remaining mozzarella

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Step 5: Bake

Cover the dish with foil and bake for 25–30 minutes. Uncover and bake an additional 10–15 minutes, or until bubbly and golden.

Let rest for 10 minutes before slicing.

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Step 6: Garnish & Serve

Sprinkle with fresh parsley, a little extra lemon zest, and serve warm with garlic bread or salad.

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Make-Ahead and Storage Tips

🧊 To store:
Cool completely and refrigerate in an airtight container for up to 4 days.

🔥 To reheat:
Cover and bake at 350°F for 20 minutes or microwave individual servings.

❄️ To freeze:
Assemble and freeze unbaked lasagna tightly wrapped. Bake from frozen at 375°F for about 1 hour, uncovering the last 15 minutes.

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What to Serve with Shrimp Scampi Lasagna

🥗 Mixed greens salad with lemon vinaigrette
🍞 Crusty garlic bread or focaccia
🍷 White wine (Pinot Grigio, Sauvignon Blanc)
🥦 Roasted asparagus or broccolini

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Recipe Variations

🧄 Extra garlicky version – Double the garlic in the butter sauce
🧀 Cheesy upgrade – Add shredded fontina or provolone
🌱 Vegetarian option – Replace shrimp with sautéed mushrooms or zucchini
🌶️ Spicy kick – Use more red pepper flakes or add diced jalapeño
🥬 Greens boost – Add a layer of wilted spinach or kale

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Nutritional Info (per serving, approx.)

• Calories: 530
• Protein: 35g
• Fat: 32g
• Carbohydrates: 28g
• Fiber: 1g
• Sodium: 820mg

Nutrition may vary based on serving size and ingredients.

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Frequently Asked Questions

Can I use frozen shrimp?

Yes — thaw and pat dry before cooking to avoid excess moisture.

Can I make it without wine?

Absolutely! Use chicken broth or seafood stock in place of white wine.

Can I use no-boil noodles?

Yes, but increase the cream slightly and cover tightly to ensure even cooking.

Can I make it gluten-free?

Use gluten-free lasagna noodles and confirm your wine or broth is gluten-free.

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Why This Recipe Works

✅ Combines the richness of lasagna with the freshness of shrimp scampi
✅ Bakes in one dish — ideal for dinner parties or Sunday meals
✅ Customizable with herbs, greens, or spice
✅ Creamy, garlicky, cheesy, and deeply satisfying

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Final Thoughts: Elegant Comfort Food Done Right

Garlic Butter Shrimp Scampi Lasagna is the best of both worlds — elegant enough to impress guests, yet comforting and familiar like a Sunday supper. It’s an indulgent, buttery, flavor-packed dish that deserves a permanent spot in your fall or winter dinner rotation.

Whether you’re serving it with a glass of white wine for date night or preparing it for a cozy holiday meal, this seafood lasagna is guaranteed to be a showstopper.

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