This Chicken Bubble Up Casserole is a warm, creamy, cheesy dinner packed with tender chicken, fluffy biscuit pieces, and rich comforting flavor in every bite. As it bakes, the biscuit dough “bubbles up” through the creamy filling, creating a soft, golden, irresistible casserole texture.

It’s one of the easiest weeknight dinners you can make using simple ingredients like cooked chicken, biscuits, cheese, and creamy sauce. Perfect for busy nights, potlucks, family dinners, or meal prep.

Why You’ll Love This Chicken Bubble Up Casserole

Easy one-pan dinner

Creamy and cheesy texture
Soft buttery biscuit topping
Family-friendly comfort food

Great use for leftover chicken
Quick prep recipe
Perfect freezer meal

Hearty and filling

What Is Bubble Up Casserole?

A bubble up casserole is a baked dish made with:

Refrigerated biscuit dough pieces

Creamy sauce
Meat or vegetables
Cheese

The biscuit pieces rise and “bubble up” while baking.

Ingredients for Chicken Bubble Up Casserole

Main Ingredients

2 cups cooked chicken (shredded or cubed)
1 can refrigerated biscuit dough

1 can cream of chicken soup
1/2 cup sour cream
1–2 cups shredded cheddar cheese

Seasonings

Garlic powder
Onion powder
Black pepper

Optional Add-Ins

Bacon
Broccoli
Ranch seasoning

Jalapeños
Corn

How to Make Chicken Bubble Up Casserole

Step 1: Prepare the Oven

Preheat oven to 350°F (175°C).

Grease casserole dish.

Step 2: Cut Biscuit Dough

Cut refrigerated biscuits into small bite-sized pieces.

Step 3: Mix Filling

Combine chicken, soup, sour cream, cheese, and seasonings.

Step 4: Add Biscuit Pieces

Fold biscuit pieces into mixture.

Step 5: Transfer to Baking Dish

Spread evenly into prepared casserole dish.

Step 6: Add Extra Cheese

Sprinkle additional cheese on top.

Step 7: Bake

Bake until bubbly, golden, and biscuits are cooked through.

Step 8: Serve Warm

Let cool slightly before serving.

Tips for the Best Bubble Up Casserole

Cut Biscuits Small

Helps them cook evenly inside casserole.

Don’t Overbake

Keeps biscuits soft and fluffy.

Use Rotisserie Chicken

Fast and flavorful shortcut.

Add Cheese in Layers

Creates gooey cheesy pockets.

Let Rest Before Serving

Helps casserole set slightly.

What Does Chicken Bubble Up Casserole Taste Like?

This casserole is:

Creamy and cheesy

Warm and buttery
Savory and comforting
Soft with fluffy biscuit texture

Rich and satisfying

It tastes like chicken pot pie meets cheesy biscuit casserole.

Variations to Try

Bacon Ranch Bubble Up

Add ranch seasoning and bacon.

Buffalo Chicken Bubble Up

Mix in buffalo sauce.

Broccoli Chicken Bubble Up

Add broccoli florets.

Mexican Bubble Up

Use taco seasoning and salsa.

Low-Carb Version

Swap biscuits for cauliflower pieces.

Best Cheese Options

Cheddar
Monterey Jack

Mozzarella
Pepper Jack
Colby Jack

What to Serve With Chicken Bubble Up Casserole

Green salad
Roasted vegetables
Garlic bread

Corn on the cob
Soup

How to Store Chicken Bubble Up Casserole

Refrigerator

Store covered up to 4 days.

Freezer

Freeze up to 2 months.

Reheating

Warm in oven for best texture.

Frequently Asked Questions

Can I use canned biscuits?

Yes, that’s the classic method.

Why is it called bubble up casserole?

Because the biscuit dough rises and bubbles while baking.

Can I make it ahead?

Yes—assemble ahead and bake later.

Can I use homemade sauce?

Absolutely—it tastes even richer.

Final Thoughts

This Chicken Bubble Up Casserole is creamy, cheesy, buttery, and packed with cozy comfort-food flavor. The fluffy biscuit pieces combined with creamy chicken filling create a hearty dinner that’s incredibly easy and always satisfying.

Perfect for busy weeknights or comforting family meals, this casserole quickly becomes a repeat favorite.

Chicken Bubble Up Casserole – Cheesy, Creamy & Ultimate Comfort Food 🥘🧀

Author: WAFA LI

Print Recipe

Instructions

1. Prep filling:

Preheat oven to 375°F (190°C).
Heat oil in large oven-safe skillet or Dutch oven over medium-high heat. Add chicken; cook 5–6 minutes until golden. Remove; set aside.

2. Sauté aromatics & veggies:

In same skillet, add onion and broccoli/green beans; cook 4–5 minutes until crisp-tender. Stir in garlic; cook 30 seconds more.

3. Make creamy sauce:

Reduce heat to low. Add cream cheese, broth, and heavy cream; whisk until smooth.
Stir in ¾ cup shredded cheese, Italian seasoning, pepper, salt, and optional bacon until melted and glossy.
Return chicken to skillet; stir to coat.

4. Make biscuit topping:

In a bowl, whisk almond flour, baking powder, and salt.
Add egg, melted butter, and Greek yogurt; mix until a soft, drop-biscuit dough forms.

5. Assemble & bake:

Drop spoonfuls of dough (about 12–15 portions) over the chicken filling—don’t spread, just drop!
Sprinkle remaining cheese over top.
Bake 30–35 minutes until topping is golden, filling is bubbly, and chicken reaches 165°F (74°C).

6. Rest & serve:

Cool 5–10 minutes. Garnish with fresh parsley and lemon zest. Serve warm.

💡 Pro Tips for Perfection:
✅ Don’t overmix biscuit dough—gentle stirring = fluffy, not dense, drops.
✅ Drop dough on warm filling—helps biscuits rise and “bubble” beautifully.
✅ Low-sodium mastery (you love this!):
→ Use reduced-sodium cheese + low-sodium broth
→ Boost umami with extra garlic, herbs, black pepper, and lemon zest
✅ Blood sugar friendly (you love this!):
→ Naturally zero-glycemic—no added sugars!
→ Net carbs: 8g per serving
✅ Low-carb/keto option (you love this!):
→ Already compliant! <9g net carbs/serving
→ High-protein: 36g+ per serving
✅ Make ahead:
→ Assemble 1 day ahead; refrigerate (add 5–10 min to bake time)
→ Keeps 4 days refrigerated or 3 months frozen

Slow Cooker Option (hands-off comfort!):

→ After prepping filling, transfer to slow cooker.
→ Cook on LOW 4–5 hours or HIGH 2–3 hours until chicken is tender.
→ Drop biscuit dough on top last 30 minutes; cover and cook until puffed.
→ Optional: Broil 2–3 minutes for golden finish!

Mini Bubble Up Cups (memory #16!):

→ Divide filling among 12 muffin cups.
→ Top each with small biscuit drop + cheese.
→ Bake at 375°F for 20–22 minutes. Perfect portion-controlled meals! 🧁✨

Flavor Variation Ideas (you love unique combos!):

→ Buffalo Chicken Bubble: Add 2–3 tbsp sugar-free buffalo sauce + blue cheese crumbles
→ Mushroom-Swiss: Swap cheddar for Swiss + add extra sautéed mushrooms
→ Spinach-Artichoke: Stir in ½ cup sugar-free artichoke hearts + extra spinach
→ Southwest: Add cumin + chili powder to filling + top with pepper jack + cilantro
→ Lemon-Herb: Add lemon zest + fresh thyme to biscuit dough for bright, fresh finish

Storage & Serving Ideas

→ Fridge life: 4 days | Freezer: 3 months (freeze before baking; thaw overnight)
→ Reheat: Oven at 350°F (175°C) for 15–20 minutes until warm
→ Serving ideas:
→ As a standalone dinner with a crisp green salad
→ Over cauliflower rice for extra volume (low-carb—you love this!)
→ For meal prep—portion into grab-and-go containers
→ For Sunday dinner, potlucks, or cozy weeknights

Prep Time & Nutrition (per serving):